Forschungsinformationssystem Universität Greifswald

Daeschlein G*¹, Napp M², Söhnel A³, von Podewils S¹, Lutze S¹, Arnold A¹, Jünger M¹

1 - Klinik und Poliklinik für Hautkrankheiten

2 - Klinik und Poliklinik für Unfall-, Wiederherstellungschirurgie und Rehabilitative Medizin

3 - Zentrum für Zahn-, Mund- und Kieferheilkunde / Poliklinik für Zahnärztliche Prothetik, Alterszahnheilkunde und Medizinische Werkstoffkunde

Photodynamic therapy (PDT) is known for over 100 years in medicine and has shown considerable power in the antimicrobial treatment of various infectious diseases involving bacteria, viruses, parasites, and fungi. In the era of worldwide emerging multi-resistance, novel treatment options are strongly warranted and PDT may be a suitable alternative to antibiotics against multidrug-resistant patho - gens. We were able to show excellent PDT (with toluidine blue as sensitizer) in vitro results against clinically highly relevant species like Methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Proteus mirabilis and Klebsiella pneumonia (extended beta-lactamase build - ner, ESBL) not being inferior in comparison to another novel treatment, cold atmospheric plasma (CAP)