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Original article | published - printed | peer reviewed | Open Access

Polypharmacy and saliva volumes in the northeast of Germany - The Study of Health in Pomerania.


COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 2022 ; 50(2): 139 - 146



https://pubmed.ncbi.nlm.nih.gov/33829548[PubMed]


Bibliometric indicators



Impact Factor = 2.3

Citations (WOS) = 2

DOI = 10.1111/cdoe.12644

PubMed-ID = 33829548


Authors

Laugisch O*1, Holtfreter B1, Pink C1, Samietz S2, Völzke H3, Kocher T1


Abstract

Objectives: Associations between saliva volumes or salivary flow rates and potentially xerogenic medication are rarely evaluated in cohorts with a wide age range. This cross-sectional cohort study investigated possible relationships between the regular consumption of potentially xerogenic medication and stimulated saliva volumes. Methods: Data from the German Studies of Health in Pomerania (SHIP-2 and SHIP-Trend-0) were pooled. Potentially xerogenic medications were identified using the Workshop on Oral Medicine VI criteria. Stimulated saliva was sampled using Salivette®, and saliva volumes expressed as μl/min were determined. Applying linear mixed models with adjustment for time point of saliva collection, associations of (a) age and sex with regularly consumed medication, (b) age and sex with saliva volumes, and (c) the number of regularly consumed xerogenic medications with saliva volumes were evaluated. Results: Six thousand seven hundred and fifty-three participants aged 20-83 years (mean 53.4 ± 14.9) were included. The average number of medications did not differ markedly between females (2.21 ± 2.46) and males (2.24 ± 2.83). Males took more potentially xerogenic medication (1.0 ± 1.3) than did females (0.9 ± 1.3). Also, males took more potentially xerogenic cardiovascular medications than did females (0.9 ± 1.2 versus 0.7 ± 1.1), while females were prescribed a higher number of potentially xerogenic medications affecting the nervous system (0.2 ± 0.5 versus 0.1 ± 0.4). The average stimulated saliva volume was 967.0 ± 433.3 µL/min. Regularly consumed and potentially xerogenic medications were associated with lower saliva volumes. Older age correlated not only with a higher number of total medications and a higher number of xerogenic medications affecting either the cardiovascular (in males) or the nervous system (in females), but also with lower saliva volumes. Conclusions: Ageing was associated with polypharmacy, especially with the intake of potentially xerogenic medication, and lower average saliva volumes. With regard to complications of dry mouth, anamnesis of medication consumption is of high importance.

Published in

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY


Year 2022
Impact Factor (2022) 2.3
Volume 50
Issue 2
Pages 139 - 146
Open Access ja
Peer reviewed ja
Article type Original article
Article state published - printed
DOI 10.1111/cdoe.12644
PubMed-ID 33829548

Common journal data

Short name: COMMUNITY DENT ORAL
ISSN: 0301-5661
eISSN: 1600-0528
Country: DENMARK
Language: English
Categories:
  • DENTISTRY, ORAL SURGERY & MEDICINE
  • PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH


Impact factor trend

Year Impact Factor
2008 1.963
2009 2.418
2010 2.328
2011 1.894
2012 1.797
2013 1.944
2014 2.025
2015 2.233
2016 2.302
2017 1.992
2018 2.278
2019 2.135
2020 3.383
2021 2.489
2022 2.3


Departments

Community Medicine
Zahnheilkunde

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