Originalartikel | erschienen - Druck | peer reviewed | Open Access
Serum lipoprotein subfractions are associated with the periodontal status – results from the population-based cohort SHIP-TREND
JOURNAL OF CLINICAL PERIODONTOLOGY
2024 / April
;
51(4):
390 - 405
Autoren
Beteiligte Einrichtungen
1 - Zentrum für Zahn-, Mund- und Kieferheilkunde / Poliklinik für Zahnerhaltung,Parodontologie, Endodontologie; Präventive Zahnmedizin und Kinderzahnheilkunde
2 - Institut für Klinische Chemie und Laboratoriumsmedizin
3 - Zentrum für Zahn-, Mund- und Kieferheilkunde / Poliklinik für Kieferorthopädie
4 - Institut für Community Medicine / Abt. SHIP KEF
Abstract
AIM: To investigate the medium-term associations of serum protein subfractions derived from proton nuclear magnetic resonance ((1) H-NMR) spectroscopy with periodontitis and tooth loss.
MATERIALS AND METHODS: A total of 3031 participants of the cohort Study of Health in Pomerania (SHIP-TREND) were included. In addition to conventional serum testing, serum lipoprotein contents and subfractions were analysed by (1) H-NMR spectroscopy. Confounder-adjusted associations of lipoprotein variables with periodontitis and the number of missing teeth variables were analysed using mixed-effects models with random intercepts for time across individuals, accounting for multiple testing.
RESULTS: While only spurious associations between lipoprotein levels from conventional blood tests were found-that is, triglycerides were associated with mean clinical attachment level (CAL) and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio with the number of missing teeth - several associations emerged from serum lipoprotein subfractions derived from (1) H-NMR analysis. Specifically, elevated LDL triglycerides were associated with higher levels of mean probing depth (PD), mean CALs, and increased odds of having <20 teeth. HDL-4 cholesterol levels were inversely associated with mean PD. Systemic inflammation (C-reactive protein) might mediate the effects of LDL and HDL triglyceride contents on periodontitis severity.
CONCLUSIONS: Several associations between serum lipoprotein subfractions and periodontitis were observed. As the underlying biochemical mechanisms remain unclear, further research is needed.
Veröffentlicht in
JOURNAL OF CLINICAL PERIODONTOLOGY
Jahr | 2024 |
Monat/Hj. | April |
Impact Factor (2024) | |
Volume | 51 |
Issue | 4 |
Seiten | 390 - 405 |
Open Access | ja |
Peer reviewed | ja |
Artikelart | Originalartikel |
Artikelstatus | erschienen - Druck |
DOI | 10.1111/jcpe.13902 |
PubMed-ID | 38098273 |
Allgemeine Daten zur Fachzeitschrift
Kurzbezeichnung: J CLIN PERIODONTOL
ISSN: 0303-6979
eISSN: 1600-051X
Land: DENMARK
Sprache: Multi-Language
Kategorie(n):
Impact Factor Entwicklung
ISSN: 0303-6979
eISSN: 1600-051X
Land: DENMARK
Sprache: Multi-Language
Kategorie(n):
- DENTISTRY, ORAL SURGERY & MEDICINE
Impact Factor Entwicklung
Jahr | Impact Factor |
---|---|
2008 | 3,193 |
2009 | 3,549 |
2010 | 3,933 |
2011 | 2,996 |
2012 | 3,688 |
2013 | 3,61 |
2014 | 4,01 |
2015 | 3,915 |
2016 | 3,477 |
2017 | 4,046 |
2018 | 4,164 |
2019 | 5,241 |
2020 | 8,728 |
2021 | 7,478 |
2022 | 6,7 |
Forschungsschwerpunkt der Universität
Beteiligte Departments
Community Medicine
Departments
Community Medicine
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