Originalartikel | erschienen - EPub | peer reviewed
Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of .
Frontiers in Immunology
2023 / September
;
14:
1229562 -
http://www.ncbi.nlm.nih.gov/pubmed/37731490[PubMed]
Autoren
Weiss S*1, Holtfreter S2, Meyer T1, Schmiedeke F2, Cammann C3, Dörr M4, Felix S, Grabe H5, Homuth G1, Kohler C3, Mahncke C2, Michalik S1, Nauck M6, Friedrich N6, Samietz S7, Völzke H8, Völker U1, Bröker B2
Beteiligte Einrichtungen
1 - Interfakultäres Institut für Genetik und Funktionelle Genomforschung / Abt. Funktionelle Genomforschung
2 - Institut für Immunologie und Transfusionsmedizin / Abt. Medizinische Immunologie
3 - Friedrich Loeffler Institut für Medizinische Mikrobiologie
4 - Zentrum für Innere Medizin / Klinik für Innere Medizin B
5 - Klinik und Poliklinik für Psychiatrie und Psychotherapie
6 - Institut für Klinische Chemie und Laboratoriumsmedizin
7 - Zentrum für Zahn-, Mund- und Kieferheilkunde / Poliklinik für Zahnärztliche Prothetik, Alterszahnheilkunde und Medizinische Werkstoffkunde
8 - Institut für Community Medicine / Abt. SHIP KEF
Abstract
Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by . A well-known risk factor is the lack of neutralizing antibodies. To identify determinants of the anti-TSST-1 antibody response, we examined 976 participants of the German population-based epidemiological Study of Health in Pomerania (SHIP-TREND-0). We measured anti-TSST-1 antibody levels, analyzed the colonization with TSST-1-encoding strains, and performed a genome-wide association analysis of genetic risk factors. TSST-1-specific serum IgG levels varied over a range of 4.2 logs and were elevated by a factor of 12.3 upon nasal colonization with TSST-1-encoding . Moreover, the anti-TSST-1 antibody levels were strongly associated with HLA class II gene loci. HLA-DRB1*03:01 and HLA-DQB1*02:01 were positively, and HLA-DRB1*01:01 as well as HLA-DQB1*05:01 negatively associated with the anti-TSST-1 antibody levels. Thus, both toxin exposure and HLA alleles affect the human antibody response to TSST-1.
Veröffentlicht in
Frontiers in Immunology
Jahr | 2023 |
Monat/Hj. | September |
Impact Factor (2023) | |
Volume | 14 |
Issue | |
Seiten | 1229562 - |
Open Access | nein |
Peer reviewed | ja |
Artikelart | Originalartikel |
Artikelstatus | erschienen - EPub |
DOI | 10.3389/fimmu.2023.1229562 |
PubMed-ID | 37731490 |
Allgemeine Daten zur Fachzeitschrift
Kurzbezeichnung: FRONT IMMUNOL
ISSN: 1664-3224
eISSN: 1664-3224
Land: SWITZERLAND
Sprache: English
Kategorie(n):
Impact Factor Entwicklung
ISSN: 1664-3224
eISSN: 1664-3224
Land: SWITZERLAND
Sprache: English
Kategorie(n):
- IMMUNOLOGY
Impact Factor Entwicklung
Jahr | Impact Factor |
---|---|
2015 | 5,695 |
2016 | 6,429 |
2017 | 5,511 |
2018 | 4,716 |
2019 | 5,085 |
2020 | 7,561 |
2021 | 8,786 |
2022 | 7,3 |
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